Endocrine Abstracts

Langerhans cell Histiocytosis is a rare neoplastic histiocytic disorder. It has broad spectrum of clinical presentations from single system to multi system. It mainly affects children but can occur in adults. It can present with skin lesions, skull/jaw tumours, polyuria/polydipsia, fever, cough and dyspnea, bone pain, ataxia etc. 25% of adult cases involve Pituitary (anterior and posterior pituitary gland) and hypothalamus. BRAF and MAP2K1 mutations are most ...

It is very rare to have Pituitary metastasis in Renal Cell cancer (RCC). Prevalence of Pituitary metastasis varies from 1-4% in all cancers and about 2.6% in RCC. Most common cancers with pituitary metastasis are breast (33%) and lung (36%). We present a rare case of RCC with pituitary Metastasis presented with severe Hyponatraemia. A 71 years old male with history of renal cell cancer who underwent Right nephrectomy in 2017. He was found to have intrathoracic metastases in 20...

Introduction: Survivors of childhood, adolescent or young adult cancers are at risk of endocrine dysfunction from their tumours, surgery, chemotherapy and/or radiotherapy treatment. The hypothalamic pituitary axes and gonads are at risk of dysfunction depending on a number of risk factors. Endocrine dysfunction can occur from before diagnosis of cancer, soon after but mostly a number of years later, even after survivors have been discharged from oncology follow-up. We aim to e...

Parathyroid hormone is a polypeptide consisting of 84 amino acids. Quantification of circulating intact PTH assists in the differential diagnosis of hypercalcemia. It is important to interpret PTH results with caution and to keep in mind Immunoassays interference can also be a reason of falsely high PTH levels. We present an interesting case referred with high parathyroid hormone levels. A 74 years old female attended clinic with raised PTH levels of 11.7 pmol/l, a normal calc...